Sensory processing in Parkinson's and Huntington's disease

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

The Relationships of Sensory Processing Sensitivity and Information Processing Styles to Clinical Symptoms in Drug-Dependent Individuals

Objective: The aim of this study was to examine the roles of sensory processing sensitivity and information processing styles in predicting clinical symptoms in drug-dependent individuals. Method: The current study was correlational-descriptive. The statistical population included all drug-dependent individuals referred to addiction treatment centers in Tabriz. Among them, 290 people were selec...

Automatic, unsupervised classification of dyskinesia in patients with Parkinsons Disease

One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...